“Atmospheric pressure plasmas operating in wide frequency range – a new tool for production of biologically relevant reactive species for applications in biomedicine”
A large variety of Atmospheric Pressure Plasma (APP) sources have been proven successful in applications in medicine, biology, stomatology, agriculture and food processing. Each of these devices was individually efficient in the targeted application. However, current knowledge in the applied fields of Plasma medicine and/or Plasma agriculture is insufficient to reach a general consensus on plasma parameters crucial for tailoring the chemistry responsible for the achieved results and whether or not they can be used for comparison between the APP sources. The scientific concept of APPerTAin-BIOM derives from the need to fill this gap in the knowledge. APPerTAinBIOM aims to tackle following challenges: to create comprehensive plasma parameter database for APP sources operating in wide frequency range (with kHz-GHz power supplies) and to interlink plasma gas phase and sample liquid phase chemistry kinetics with obtained set of measurable plasma parameters and biomedical models (plant calli, drug resistant bacterial strains). In order to enclose these challenges, an extensive diagnostics of plasma systems will be performed and a detailed electrical model will be developed. The aim is to unify information from plasma physics and induced biochemistry in order to define standard protocols and procedures for treatments and give guidelines for comparison of different APP sources, which will be an important breakthrough for plasma biomedical treatments. The major scientific impacts of APPerTAin-BIOM will be: to significantly improve the understanding of the plasma chemistry at atmospheric pressure and the means for its tailoring; to define main plasma parameters that can be confidently used as markers for plasma efficiency. Wider impact of APPerTAin-BIOM is directed to the healthcare systems through providing a complete image of the innovative and cutting-edge biotechnological process that involves APP technology for drug-resistant bacteria.
Participating Scientific and Research Organizations (SROs):
Institute of Physics, University of Belgrade
IPB
Faculty of Medicine, University of Belgrade
MFUB
School of Dental Medicine, University of Belgrade
STOMF
Institute for Biological Research “Siniša Stanković”, University of Belgrade
IBISS